Hormone replacement therapy and prevention of nonvertebral fractures: a meta-analysis of randomized trials.

  title={Hormone replacement therapy and prevention of nonvertebral fractures: a meta-analysis of randomized trials.},
  author={David J. Torgerson and Sally E. M. Bell-Syer},
  volume={285 22},
CONTEXT Hormone replacement therapy (HRT) is widely considered to reduce fractures, but this belief is based on observational data; evidence from randomized trials is lacking. OBJECTIVE To conduct a systematic review of all randomized trials of HRT that have reported or collected nonvertebral fracture data but that may not have focused on fracture prevention. DATA SOURCES The MEDLINE, EMBASE, Science Citation Index, and Cochrane Controlled Trials Register databases were searched from 1997… 

V. Meta-Analysis of the Efficacy of Hormone Replacement Therapy in Treating and Preventing Osteoporosis in Postmenopausal Women

HRT has a consistent, favorable and large effect on bone density at all sites, and the data show a nonsignificant trend toward a reduced incidence in vertebral and nonvertebral fractures.

Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials

A review and meta-analysis of randomised trials of HRT showed a significant reduction in vertebral fractures associated with HRT use.

Effect of hormone therapy on the risk of bone fractures: a systematic review and meta-analysis of randomized controlled trials

HT is associated with a reduced risk of total, hip, and vertebral fractures, with a possible attenuation of this protection effect after it is stopped or when it is begun after 60 years, however, there may be an increase in the incidence of thrombus formation associated with HT.

Postmenopausal hormone replacement therapy: scientific review.

Benefits of HRT include prevention of osteoporotic fractures and colorectal cancer, while prevention of dementia is uncertain, according to a meta-analysis of 22 estrogen trials, cohort studies, results of the WHI, and trials with bone density outcomes.

Economic evaluations of interventions for the prevention and treatment of osteoporosis: a structured review of the literature

A structured review of economic evaluations of interventions to prevent and treat osteoporosis found that hormone replacement therapy, bisphosphonates and combinations of vitamin D and calcium were the main interventions investigated, and hip fracture was the sole fracture outcome.

High-intensity resistance training and postmenopausal bone loss: a meta-analysis

Methodological quality of all included studies was low, and a reporting bias towards studies with positive BMD outcomes was evident, which is relevant to the nonpharmacological treatment of postmenopausal bone loss.

Menopausal hormone therapy and women’s health: An umbrella review

An umbrella review to comprehensively summarize evidence on the benefits and harms of MHT across diverse health outcomes found that MHT has a complex balance of benefits and harm on multiple health outcomes.

Fracture prevention in postmenopausal women.

A systematic review of the effects of treatments to prevent fractures in postmenopausal women found information relating to the effectiveness and safety of the following interventions: alendronate, calcitonin, calcium, calcium plus vitamin D, clodronate and vitamin D analogues.



Variation in the Efficacy of Hormone Replacement Therapy in the Prevention of Hip Fracture

The observed interactions with weight and physical activity suggest that HRT has the best protective effect against hip fracture among high-risk women.

Impact of postmenopausal hormone therapy on cardiovascular events and cancer: pooled data from clinical trials

The results of pooled data do not support the notion that postmenopausal hormone therapy prevents cardiovascular events, and the numbers of reported events were too low for a useful conclusion.

Estrogen Replacement Therapy and Fractures in Older Women

This study examined the association between estrogen use and bone mass in elderly women and found the protective effects of estrogen on fracture were greater in younger women and weaker in older women, as well as the relation between unopposed estrogen and fractures.

Effect of age on reasons for initiation and discontinuation of hormone replacement therapy.

Whereas osteoporosis is the predominant reason that older women begin HRT, relief of vasomotor symptoms is the major reason that younger women begin, and early discontinuation of HRT is greater among older women.

The Prevention of Osteoporosis Using Sequential Low-Dose Hormone Replacement Therapy with Estradiol-17β and Dydrogesterone

One milligram estradiol-17β in combination with dydrogesterone is effective in conserving LS and proximal femur bone mass, both of which are clinically important sites of osteoporotic fracture, and is as effective as 2 mg in preventing FN bone.

Treatment of postmenopausal osteoporosis with transdermal estrogen.

Transdermal estradiol treatment is effective in postmenopausal women with established osteoporosis and vertebral fractures and Histomorphometric evaluation of iliac biopsy samples confirmed the effect of estrogen on bone formation rate per bone volume.