Hormone replacement therapy: prothrombotic vs. protective effects.

  • Gordon D O Lowe
  • Published 2002 in Pathophysiology of haemostasis and thrombosis


Hormone replacement therapy (HRT) is associated with reduced risk of coronary heart disease (CHD) and stroke in observational studies; however the possibility of confounding by other risk factors requires prospective assessment of its risks and benefits in randomised controlled trials. The HERS trial of oral HRT in secondary CHD prevention observed an early… (More)


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