Hormone-induced secretory and nuclear translocation of calmodulin: oscillations of calmodulin concentration with the nucleus as an integrator.

@article{Craske1999HormoneinducedSA,
  title={Hormone-induced secretory and nuclear translocation of calmodulin: oscillations of calmodulin concentration with the nucleus as an integrator.},
  author={Madeleine Craske and Teruko Takeo and Oleg V Gerasimenko and Camille Vaillant and Katalin T{\"o}r{\"o}k and Ole H Petersen and Alexei V Tepikin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 8},
  pages={4426-31}
}
Many important enzyme activities are regulated by Ca2+-dependent interactions with calmodulin (CaM). Some of the most important targets for CaM action are in the nucleus, and Ca2+-dependent CaM translocation into this organelle has been reported. Hormone-evoked cytosolic Ca2+ signals occur physiologically as oscillations, but, so far, oscillations in CaM concentration have not been described. We loaded fluorescent-labeled CaM into pancreatic acinar cells and monitored the fluorescence in… CONTINUE READING