Hormone-independent, non-alkylating mechanism of cytotoxicity for estramustine

  title={Hormone-independent, non-alkylating mechanism of cytotoxicity for estramustine},
  author={Kenneth D. Tew and Mark E. Stearns},
  journal={Urological Research},
Over two decades, experience with estramustine has provided limited data which support an estrogenic mechanism of action and no data which indicate the nitrogen mustard involvement in the cytotoxic properties of the drug. Consideration of the carbamate-ester portion of estramustine supports the pharmacokinetic evidence that estramustine has a long half life since enzymatic hydrolysis of the carbamate is an uncommon event. Using a variety of immunocytochemical and cellular morphology procedures… CONTINUE READING


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