Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells

Abstract

In breast cancer cells, cytoplasmic localization of the estradiol receptor alpha (ERalpha) regulates estradiol-dependent S phase entry. We identified a nuclear export sequence (NES) in ERalpha and show that its export is dependent on both estradiol-mediated phosphatidylinositol-3-kinase (PI3K)/AKT activation and chromosome region maintenance 1 (CRM1). A Tat… (More)
DOI: 10.1083/jcb.200712125

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