Hormone dependence in premalignant mammary progression.

  title={Hormone dependence in premalignant mammary progression.},
  author={Daniel C Medina and Frances S. Kittrell and Anne Shepard and Alejandro Ernesto Contreras and Jeffrey M. Rosen and John P. Lydon},
  journal={Cancer research},
  volume={63 5},
Human breast cancers that are estrogen receptor (ER) negative convey a poor prognosis for patient survival. A mouse model that mimics essential biological and genetic attributes of a subset of human breast cancer is the BALB/c p53-null mammary epithelium, in which deletion of the tumor suppressor gene p53 results in enhanced tumorigenic risk. The experiments reported herein examine the hormone dependence of premalignant mammary progression in this model. The p53-null normal mammary epithelium… CONTINUE READING


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