Hormone-Induced Sexual Differentiation of Brain and Behavior in Zebra Finches

@article{Gurney1980HormoneInducedSD,
  title={Hormone-Induced Sexual Differentiation of Brain and Behavior in Zebra Finches},
  author={M. Gurney and M. Konishi},
  journal={Science},
  year={1980},
  volume={208},
  pages={1380 - 1383}
}
The male zebra finch sings, whereas the female does not. This behavioral dimorphism is correlated with the presence of morphological sex differences within the neural substrate that mediates this behavior, the song system. When a female chick is exposed to 17β-estradiol her song system is subsequently masculinized. Either testosterone or 5α-dihydrotestosterone may then induce such a female to sing when an adult. 
Behavioral correlates of sexual differentiation in the zebra finch song system
The capacity for song is masculinized in female zebra finches by exposure to 17 beta-estradiol at hatching, and requires continual exposure to androgen for its behavioral expression in the adult. TheExpand
The correlation between the degree of brain masculinization and song quality in estradiol treated female zebra finches
TLDR
The anatomy of two song nuclei is compared with the birds' song quality and the capacity for song correlates with the volumes of the nucleus hyperstriatum, ventralis, pars caudalis, HVc and the nucleus robustus archistriatalis and with the size of RA neurons. Expand
Reanalyzing the role of estradiol in the developing zebra finch brain
In zebra finches, many features of the neural song system are more pronounced in males compared to females. The exact mechanism(s) responsible for these differences are not known, but potentiallyExpand
Estrogen establishes sex differences in androgen accumulation in zebra finch brain
TLDR
It is suggested that early E2 exposure renders the female song system neuroanatomically and functionally responsive to androgens, and E2 establishes this responsiveness by regulating the number of androgen target neurons within MAN and HVc. Expand
Sexual differentiation of brain and behavior in quail and zebra finches: Studies with a new aromatase inhibitor, R76713
TLDR
It was proposed that the male reproductive phenotype is "neutral" in birds and that endogenous estradiol secreted by the ovary of the female embryo is responsible for the physiological demasculinization of females and this model could be recently confirmed. Expand
Neither testicular androgens nor embryonic aromatase activity alters morphology of the neural song system in zebra finches.
TLDR
It is found that treating embryonic female zebra finches with fadrozole, a potent aromatase inhibitor, can induce testicular tissue to develop in addition to normal ovarian tissue, and shows that it secretes androgens in adulthood, produces sperm, and causes the androgen-sensitive syrinx to enlarge. Expand
Sexual differentiation of behavior in the zebra finch: Effect of early gonadectomy or androgen treatment
TLDR
Androgens appear to have less influence than estrogens on sexual differentiation of behavior in this species, and the combination of DHTP and EB demasculinized mounting in males. Expand
Zebra finch sexual differentiation: The aromatization hypothesis revisited
  • J. Wade
  • Biology, Medicine
  • Microscopy research and technique
  • 2001
TLDR
The evidence relating to the role of gonadal steroids in the sexual differentiation of reproductive behaviors and the central and peripheral structures known to regulate them in zebra finches are reviewed, with a focus on estradiol, which has been most extensively studied in the masculinization of song system morphology and function. Expand
Testosterone Metabolism and Sexual Differentiation in Quail
TLDR
In higher vertebrates, sexual dimorphism is a widespread phenomenon and males and females usually differ in their behaviour and endocrine physiology. Expand
Post-hatching inhibition of aromatase activity does not alter sexual differentiation of the zebra finch song system
TLDR
The results argue against the importance of estrogen in masculinization of the song system in males after hatching. Expand
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