Hormone Binding by Human Mammary Carcinoma1


The specific binding of labeled porcine insulin, human prolactin, and human growth hormone was studied in 63 human breast tumors and 15 nonmalignant breast tissues. Most (90%) of the tumors demonstrated significant binding of insulin, as did 80% of nonmalignant tissues. Autoradiographie studies indicated that insulin bound dominantly to tumor cells, rather… (More)


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