Hormonally-regulated proteins in breast secretions are markers of target organ sensitivity

  title={Hormonally-regulated proteins in breast secretions are markers of target organ sensitivity},
  author={Clifford Harding and O Osundeko and Lynne C. Tetlow and Eric Brian Faragher and Anthony Howell and Nigel J. Bundred},
  journal={British Journal of Cancer},
  pages={354 - 360}
Anti-oestrogen therapy is being used in an attempt to prevent breast cancer but no intermediate end points of the effect of tamoxifen on the normal breast are available. Therefore, the purpose of this study was to develop a physiological measure of oestrogen action on the breast. We measured oestrogen-stimulated and -inhibited proteins in breast secretions from women on and off anti-oestrogen therapy. Two oestrogen-stimulated proteins (pS2 and cathepsin D) and oestrogen-inhibited proteins (CP15… CONTINUE READING


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