Hormonally-regulated proteins in breast secretions are markers of target organ sensitivity

@article{Harding2000HormonallyregulatedPI,
  title={Hormonally-regulated proteins in breast secretions are markers of target organ sensitivity},
  author={Clifford Harding and O Osundeko and Lynne C. Tetlow and Eric Brian Faragher and Anthony Howell and Nigel J. Bundred},
  journal={British Journal of Cancer},
  year={2000},
  volume={82},
  pages={354 - 360}
}
Anti-oestrogen therapy is being used in an attempt to prevent breast cancer but no intermediate end points of the effect of tamoxifen on the normal breast are available. Therefore, the purpose of this study was to develop a physiological measure of oestrogen action on the breast. We measured oestrogen-stimulated and -inhibited proteins in breast secretions from women on and off anti-oestrogen therapy. Two oestrogen-stimulated proteins (pS2 and cathepsin D) and oestrogen-inhibited proteins (CP15… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Influence of pregnancy and lactation on serum and breast fluid oestrogen levels : implications for breast cancer risk

  • NL Petrakis, JM Lowenstein, +4 authors R Miike
  • Int J Cancer
  • 1987
Highly Influential
4 Excerpts

The influence of antioestrogens on pS 2 cathepsin D mRNA induction in MCF7 breast cancer cells

  • LM Sanchez, F Visozo
  • Anticancer Res
  • 1996

Identification of the major protein components in breast secretions from women with benign a malignant breast diseases

  • LM Sanchez, F Visozo, I Diez-Itza, C Lopez-Otin
  • Cancer Res
  • 1992

Review of GCD

  • DE Haagensen, WG Dilley, G Mazoujian, SA Wells
  • 1990
1 Excerpt

Review of GCD 15

  • C Harding
  • Ann NY Acad Sci
  • 1990

Similar Papers

Loading similar papers…