Hormonal therapy and sex reassignment: a systematic review and meta‐analysis of quality of life and psychosocial outcomes

  title={Hormonal therapy and sex reassignment: a systematic review and meta‐analysis of quality of life and psychosocial outcomes},
  author={Mohammad Hassan Murad and Mohamed B. Elamin and Magaly Zumaeta Garcia and Rebecca J. Mullan and Ayman Murad and Patricia J. Erwin and Victor M. Montori},
  journal={Clinical Endocrinology},
Objective  To assess the prognosis of individuals with gender identity disorder (GID) receiving hormonal therapy as a part of sex reassignment in terms of quality of life and other self‐reported psychosocial outcomes. 

A Systematic Review of the Effects of Hormone Therapy on Psychological Functioning and Quality of Life in Transgender Individuals

Hormone therapy interventions to improve the mental health and quality of life in transgender people with gender dysphoria have not been evaluated in controlled trials and low quality evidence suggests that hormone therapy may lead to improvements in psychological functioning.

Is hormonal therapy associated with better quality of life in transsexuals? A cross-sectional study.

A positive effect of hormone therapy on transsexuals' QoL is suggested after accounting for confounding factors, which will be useful for healthcare providers of transgender persons but should be confirmed with larger samples using a prospective study design.

Cross‐sex hormone therapy in Australia: the prescription patterns of clinicians experienced in adult transgender healthcare

Despite increasing demand for transgender healthcare, guidelines for cross‐sex hormone therapy are based on low‐level evidence only. As most data are based on international expert opinions,

Hormone Therapy for Transgender Men.

Informed consent and childhood gender dysphoria: emerging complexities in diagnosis and treatment

Some of the emerging complexities in the management of childhood gender dysphoria are explored to raise questions about the gender-affirmation approach and highlight concerns about informed consent and research ethics.

Endocrine care of transpeople part I. A review of cross‐sex hormonal treatments, outcomes and adverse effects in transmen

Monitoring of transmen should be more frequent during the first year of cross‐sex hormone administration reducing to once or twice per year thereafter, and long‐term monitoring after sex reassignment surgery (SRS) includes annual check‐ups as are carried out for natal hypogonadal men.

The effect of cross-sex hormones on the quality of life, depression and anxiety of transgender individuals: a quantitative systematic review.

Transgender participants who were prescribed cross-sex hormones had statistically significant scores demonstrating improvement on the validated scales that measured quality of life, anxiety and depression when compared to transgender people who had enrolled in a sex-reassignment clinic but had not yet begun taking cross- sex hormones.

Safety of hormonal treatment in transgenders

Treatment must be highly individualized and transitioning patients need to be engaged in a ‘clinical contract’ with the physician in order to ensure compliance with prescribed treatments.

The effect of cross-sex hormonal treatment on gender dysphoria individuals’ mental health: a systematic review

It is indicated that gender dysphoria-related mental distress may benefit from hormonal treatment intervention, suggesting a transient reaction to the nonsatisfaction connected to the incongruent body image rather than a stable psychiatric comorbidity.

Approach to the Patient: Pharmacological Management of Trans and Gender-Diverse Adolescents

Current treatment options, reported outcomes, and clinical challenges in the pharmacological management of trans and gender-diverse adolescents are reviewed.



[Results of sex change operations in 30 transsexual patients: psychosocial and sexual adaptation--surgical complications].

  • H. KaubeE. Biemer
  • Psychology, Medicine
    Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...
  • 1991
Ten male and twenty female transsexual patients who had undergone sex reassignment surgery were followed-up with regard to postoperative complications, partner and sexual interaction and their

Mortality and morbidity in transsexual subjects treated with cross‐sex hormones

Investigation of mortality and morbidity figures in a large group of transsexual subjects receiving cross‐sex hormone treatment finds that the optimum steroid hormone treatment regimes for transsexual subjects has not yet been established.

New women: Sexological outcomes of male-to-female gender reassignment surgery

This research study investigated sexological outcomes of gender reassignment surgery in 17 postoperative male-to-female transsexuals (new women) and identified the best predictors of good sexual functioning and sexual satisfaction.

Sexual and Physical Health After Sex Reassignment Surgery

After SRS, the transsexual person's expectations were met at an emotional and social level, but less so at the physical and sexual level even though a large number of transsexuals (80%) reported improvement of their sexuality.

Sex reassignment of adolescent transsexuals: a follow-up study.

Starting the sex reassignment procedure before adulthood results in favorable postoperative functioning, provided that careful diagnosis takes place in a specialized gender team and that the criteria for starting the procedure early are stringent.

Presurgical Adjustment in Male Transsexuals with and without Hormonal Treatment

It is further suggested that personality research with presurgical transsexuals include a drug hormone history and a more rigorous criteria for psychopathology may be required for those persons already exposed to hormonal therapy.

Adolescents with gender identity disorder who were accepted or rejected for sex reassignment surgery: a prospective follow-up study.

Careful diagnosis and strict criteria are necessary and sufficient to justify hormone treatment in adolescent transsexuals and the high levels of psychopathology found in this group justify the decision to not start hormone treatment too soon or too easily.

Men as women:Experiences from five cases after administrative, hormonal, and surgical treatment

Five biological men who have been observed in their roles as women for a period of 6 to 12 years since undergoing a complete sex change are described.

Sex reassignment surgery: A study of 141 dutch transsexuals

It is concluded that there is no reason to doubt the therapeutic effect of sex reassignment surgery and that more attention ought to be paid to psychosocial guidance in addition to medical guidance.