Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells.

  title={Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells.},
  author={Belinda M Hardman and Agnes A. Michalczyk and Mark A. Greenough and James Camakaris and Julian F. B. Mercer and Margaret Leigh Ackland},
  journal={The Biochemical journal},
  volume={402 2},
Copper deficiency during pregnancy results in early embryonic death and foetal structural abnormalities including skeletal, pulmonary and cardiovascular defects. During pregnancy, copper is transported from the maternal circulation to the foetus by mechanisms which have not been clearly elucidated. Two copper-transporting ATPases, Menkes (ATP7A; MNK) and Wilson (ATP7B; WND), are expressed in the placenta and both are involved in placental copper transport, as copper accumulates in the placenta… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 21 extracted citations

Wilson disease in children.

Handbook of clinical neurology • 2017
View 1 Excerpt

Copper trafficking to the secretory pathway.

Metallomics : integrated biometal science • 2016

Effects of Octylphenol and Bisphenol A on the Metal Cation Transporter Channels of Mouse Placentas

International journal of environmental research and public health • 2016
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 41 references

Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites

M. Cater, J. R. Forbes, S. La Fontaine, D. W. Cox, J. F. Mercer
Biochem. J. 380, • 2004

Functional properties of the copper-transporting ATPase ATP7B (the Wilson’s disease protein) expressed in insect cells

R. Tsivkovskii, J. F. Eissis, J. H. Kaplan, S. Lutsenko
J. Biol • 2002

Effect of cyclic

R. Coya, O. Gualillo, +5 authors R. M. Senaris

Similar Papers

Loading similar papers…