Corpus ID: 24478418

Hormonal regulation of microsomal flavin-containing monooxygenase: tissue-dependent expression and substrate specificity.

@article{Lemoine1991HormonalRO,
  title={Hormonal regulation of microsomal flavin-containing monooxygenase: tissue-dependent expression and substrate specificity.},
  author={A. Lemoine and D. Williams and T. Cresteil and J. Leroux},
  journal={Molecular pharmacology},
  year={1991},
  volume={40 2},
  pages={
          211-7
        }
}
The substrate- and tissue-dependent hormonal regulation of flavin-containing monooxygenase (EC 1.14.13.8) was studied in male and female rats. Hypophysectomy of males reduced liver microsomal N,N-dimethylaniline N-oxidation, thiobenzamide S-oxidation, and imipramine N-oxidation, although the reduction was not as marked with the latter substrate. Castration also reduced flavin-containing monooxygenase-dependent activities, but not to the same extent as hypophysectomy. Administration of growth… Expand
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