Hormonal regulation of hepatic organic anion transporting polypeptides.

@article{Wood2005HormonalRO,
  title={Hormonal regulation of hepatic organic anion transporting polypeptides.},
  author={Marcie Wood and Meenakshisundaram Ananthanarayanan and Brendan T Jones and Ruth Wooton-Kee and Tim Hoffman and Frederick J. Suchy and Mary Vore},
  journal={Molecular pharmacology},
  year={2005},
  volume={68 1},
  pages={218-25}
}
Organic anion transporting polypeptides (Oatp) mediate the transport of a wide variety of amphipathic organic substrates. Rat Oatp1b2 and human OATP1B3 are members of a liver-specific subfamily of Oatps/OATPs. We investigated whether prolactin (PRL) and growth hormone (GH) regulated Oatp1b2 and OATP1B3 gene expression via signal transducers and activators of transcription 5 (Stat5). Binding sites for Stat5 transcription factors were located in the promoters of Oatp1b2 and OATP1B3 at -209 to… CONTINUE READING

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