Hormonal regulation of glycosaminoglycan accumulation in fibroblasts from patients with resistance to thyroid hormone.
@article{Murata1983HormonalRO, title={Hormonal regulation of glycosaminoglycan accumulation in fibroblasts from patients with resistance to thyroid hormone.}, author={Y. Murata and S. Refetoff and A. L. Horwitz and T. J. Smith}, journal={The Journal of clinical endocrinology and metabolism}, year={1983}, volume={57 6}, pages={ 1233-9 } }
We have previously shown that physiological concentrations of T3 added to thyroid hormone-deficient media decreased the incorporation of [3H]acetate and [3H]glucosamine into glycosaminoglycans (GAG) in confluent cultures of skin fibroblasts obtained from normal individuals. This inhibitory effect of T3 on [3H]GAG accumulation was due to a decrease in GAG synthesis, was independent of the substrate pool size or number of transfers in culture, and could be reversed by removal of hormone from the… CONTINUE READING
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