Hormonal regulation of glycosaminoglycan accumulation in fibroblasts from patients with resistance to thyroid hormone.

@article{Murata1983HormonalRO,
  title={Hormonal regulation of glycosaminoglycan accumulation in fibroblasts from patients with resistance to thyroid hormone.},
  author={Y. Murata and S. Refetoff and A. L. Horwitz and T. J. Smith},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1983},
  volume={57 6},
  pages={
          1233-9
        }
}
  • Y. Murata, S. Refetoff, +1 author T. J. Smith
  • Published 1983
  • Biology, Medicine
  • The Journal of clinical endocrinology and metabolism
    • We have previously shown that physiological concentrations of T3 added to thyroid hormone-deficient media decreased the incorporation of [3H]acetate and [3H]glucosamine into glycosaminoglycans (GAG) in confluent cultures of skin fibroblasts obtained from normal individuals. This inhibitory effect of T3 on [3H]GAG accumulation was due to a decrease in GAG synthesis, was independent of the substrate pool size or number of transfers in culture, and could be reversed by removal of hormone from the… CONTINUE READING
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