Hormonal regulation of glucose and system A amino acid transport in first trimester placental villous fragments.

@article{Ericsson2005HormonalRO,
  title={Hormonal regulation of glucose and system A amino acid transport in first trimester placental villous fragments.},
  author={Anette Ericsson and B. Hamark and Nina Jansson and Bengt R. Johansson and Theresa L Powell and Thomas Jansson},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2005},
  volume={288 3},
  pages={
          R656-62
        }
}
  • A. Ericsson, B. Hamark, +3 authors T. Jansson
  • Published 1 March 2005
  • Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
Alterations in placental nutrient transfer have been implicated in fetal growth abnormalities. In pregnancies complicated by diabetes and accelerated fetal growth, upregulations of glucose transporter 1 (GLUT1) and amino acid transporter system A have been shown in the syncytiotrophoblast of term placenta. In contrast, intrauterine growth restriction is associated with a downregulation of placental system A transporters. However, underlying mechanisms of transporter regulation are poorly… 
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Evaluating the impact of maternal hypercholesterolemia during rabbit gestation on the glucose metabolism and the routing of glucose transporters (SLC2 and SLC5 [previously known as GLUT and SGLT]) in placenta shows that maternal hyper cholesterolemic activity induces offspring hypoglycemia and reduces the cell surface expression of placental SLC2A1.
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TLDR
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