Hormonal regulation of estrogen receptor messenger ribonucleic acid in T47Dco and MCF-7 breast cancer cells.

@article{Berkenstam1989HormonalRO,
  title={Hormonal regulation of estrogen receptor messenger ribonucleic acid in T47Dco and MCF-7 breast cancer cells.},
  author={Anders Berkenstam and Hans Glaumann and Michael Martin and J A Gustafsson and Gunnar Norstedt},
  journal={Molecular endocrinology},
  year={1989},
  volume={3 1},
  pages={22-8}
}
Using a combination of hormone-binding assays, immunologic techniques, and mRNA hybridizations we have measured the estrogen receptor (ER) content and studied the hormonal regulation of ER mRNA in one estrogen responsive and one estrogen unresponsive breast cancer cell line, MCF-7 and T47Dco, respectively. Estradiol binding could be detected in cytosol from MCF-7 cells but not in T47Dco cells. However, when measured by an enzyme-linked immunosorbent assay, T47Dco cells were found to contain… CONTINUE READING

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