Hormonal regulation of cholinephosphate cytidylyltransferase in human fetal lung.

@article{Sharma1993HormonalRO,
  title={Hormonal regulation of cholinephosphate cytidylyltransferase in human fetal lung.},
  author={Anita Sharma and Linda W. Gonzales and Philip L. Ballard},
  journal={Biochimica et biophysica acta},
  year={1993},
  volume={1170 3},
  pages={237-44}
}
Cytidylyltransferase (CTP: cholinephosphate cytidylyltransferase, EC 2.7.7.15, CYT) is a regulatory enzyme for synthesis of pulmonary surfactant phosphatidylcholine (PC). The effects of glucocorticoid, T3, and cAMP on CYT activity were studied in explants of human fetal lung (18-22 weeks gestation) cultured for 1-6 days in serum-free medium. Dexamethasone (Dex, 10 nM) treatment for 5 days increased homogenate CYT activity (+115%, P < 0.02) when assayed in the presence of added lipid co-factor… CONTINUE READING

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