Hormonal regulation of a polyoma virus middle-size T-antigen gene linked to growth hormone control sequences.

Abstract

We constructed a recombinant DNA gene containing sequences from the 5' flanking region of a dexamethasone-inducible rat growth hormone gene linked to the coding region of the polyoma virus transforming protein, the middle-size T (MT) antigen. We used this gene to derive cell lines in which the expression of the MT antigen could be regulated by dexamethasone… (More)

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