Hormonal regulation of Mg2+ transport and homeostasis in eukaryotic cells

@article{Romani2004HormonalRO,
  title={Hormonal regulation of Mg2+ transport and homeostasis in eukaryotic cells},
  author={Andrea M. P. Romani and Michael E. Maguire},
  journal={Biometals},
  year={2004},
  volume={15},
  pages={271-283}
}
The high concentrations of total and free magnesium (Mg2+ f ) within eukaryotic cells and its role as an essential co-factor or regulator for numerous cellular enzymes and functions surprisingly contrasts with the minimal knowledge of the mechanisms, genes and proteins that regulate Mg2+ homeostasis at the cellular and organismal level. The reasons for this limited knowledge are both conceptual and methodological. Conceptually, the abundance of intracellular Mg2+ has led to the idea that no… 
Magnesium homeostasis in mammalian cells.
  • A. Romani
  • Biology
    Frontiers in bioscience : a journal and virtual library
  • 2007
TLDR
This work will attempt to provide a comprehensive framework of the modalities by which cellular Mg2+ homeostasis and transport are regulated, as well as examples of cellular functions regulated by changes in cellular M g2+ level.
Regulation of the Alr1 transporter by Mg supply
TLDR
To better understand how the expression and activity of this key Mg transporter is regulated by Mg supply in yeast, the Alr1 protein was suspected to be modified by phosphorylation under Mg-replete conditions.
Cellular magnesium homeostasis.
  • A. Romani
  • Biology
    Archives of biochemistry and biophysics
  • 2011
Regulation of magnesium homeostasis and transport in mammalian cells.
  • A. Romani
  • Biology
    Archives of biochemistry and biophysics
  • 2007
Mg2+ transport in the kidney
TLDR
Details of the transport processes and the mechanisms by which they control Mg2+ excretion must await cloning of renal M g2+ transporters and/or channels, which would provide new concepts in the understanding of kidney Mg 2+ handling.
Magnesium homeostasis in Mammalian cells.
  • A. Romani
  • Biology
    Metal ions in life sciences
  • 2013
TLDR
This chapter will provide an assessment of the various mechanisms controlling cellular Mg(2+) homeostasis and transport, and the implications changes in cellular MG( 2+) content play under physiological and pathological conditions.
Physiology of epithelial Ca2+ and Mg2+ transport.
TLDR
The processes of epithelial Ca2+ and Mg2+ transport, the molecular mechanisms involved, and the various forms of regulation are reviewed.
Magnesium transporters: properties, regulation and structure.
  • M. Maguire
  • Biology
    Frontiers in bioscience : a journal and virtual library
  • 2006
TLDR
Prokaryotes carry three classes of Mg2+ transport systems: CorA, MgtA/B and MgtE, which belong to the P-type ATPase superfamily, but mediate Mg 2+ influx down its electrochemical gradient rather than against the gradient as with other P- type ATPases.
Regulation of Respiration by Cellular Key Parameters: Energy Demand, ADP, and Mg 2+
TLDR
Results summarized in this chapter show that the cytosolic concentrations of free ADP and free Mg2+, rather than the ATP/ADP ratio (or the energy charge), are the key factors adjusting cellular respiratory activity to the metabolic Mg-ATP demand.
Release of Ca2+ and Mg2+ from yeast mitochondria is stimulated by increased ionic strength
TLDR
The efflux of Ca2+ and Mg2+ from yeast mitochondria was characterized and release was activated by increased ionic strength, likely an important mechanism in the regulation of mitochondrial matrix space divalent cation concentrations.
...
...

References

SHOWING 1-10 OF 161 REFERENCES
Hormonal control of Mg2+ transport in the heart
TLDR
It is shown that noradrenaline, through β-adrenergic stimulation and increase of cyclic AMP, stimulates a large efflux of Mg2+ from cardiac cells, and this transport is of major dimensions and can move up to 20% of total cellular Mg 2+ within a few minutes.
Regulation of cell magnesium.
Magnesium as a regulatory cation: criteria and evaluation.
TLDR
There exists strong but as yet incomplete evidence that Mg2+, like Ca2+, can play an active, regulatory role within cells, and it is suggested that Ca2+ plays the specific role of the acute, transient regulatory element while M g2+ play the complementary role of a more long-term regulatory element which controls the set point or gain of a system or process.
Cloning and characterization of a novel Mg2+/H+ exchanger
TLDR
The cloning and characterization of an Arabidopsis thaliana transporter, designated AtMHX, is reported, which is localized in the vacuolar membrane and functions as an electrogenic exchanger of protons with Mg2+ and Zn2+ ions.
Characterization of two Mg2+transporters in sealed plasma membrane vesicles from rat liver.
The plasma membrane of mammalian cells possesses rapid Mg2+ transport mechanisms. The identity of Mg2+ transporters is unknown, and so are their properties. In this study, Mg2+ transporters were
Magnesium homeostasis in cardiac cells
TLDR
The results of these investigations suggest that Ca 2+ and H+ can modulate [Mg2+]i, probably by affecting cytosolic Mg 2+ binding and/or subcellular M g2+ transport and that such redistribution of intracellular Mg1+ may play an important role in Mg2- homeostasis in cardiac cells.
Differential compartmentation of magnesium and calcium in murine S49 lymphoma cells.
TLDR
Under appropriate conditions, the digitonin permeabilization technique allows determination of the amount of a particular cell constituent within the solute space of the cytoplasm, suggesting compartmentation of Mg2+ may be dependent on proliferative status.
Hormonal stimulation of Mg2+ uptake in hepatocytes. Regulation by plasma membrane and intracellular organelles.
Microbial magnesium transport: unusual transporters searching for identity
TLDR
The physiological roles of the known Mg2+ transport systems are not yet completely defined, but the singular sequence and apparent structure of the CorA and MgtE transport proteins, the complex regulation of MgtA, MgtB and MGTC and their involvement in pathogenesis suggests that further study will be rewarding.
Cellular magnesium and Na/Mg exchange in heart cells.
TLDR
Questions that remain to be answered relate to whether the pathologic effects of altered plasma magnesium are mediated primarily by alterations in extracellular magnesium (Mgo), by a secondary alteration in Mgj, or by the combined effect of the two mechanisms.
...
...