Hormonal regulation of K+-channel messenger RNA in rat myometrium during oestrus cycle and in pregnancy

@article{Boyle1987HormonalRO,
  title={Hormonal regulation of K+-channel messenger RNA in rat myometrium during oestrus cycle and in pregnancy},
  author={Mary B. Boyle and Neil J Maclusky and Frederick Naftolin and Leonard K Kaczmarek},
  journal={Nature},
  year={1987},
  volume={330},
  pages={373-375}
}
The dramatic enhancement of smooth-muscle excitability in the uterus which occurs at oestrus and at term in pregnant rats is closely related to increased blood oestrogen concentrations1–4. How oestrogen alters the electrical properties of myometrial cells is unclear, although electrical coupling between cells has been shown to increase5–9. Many examples are known of changes in cellular excitability involving modification of existing ion channels by second-messenger pathways10. Steroid hormones… CONTINUE READING

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