Hormonal regulation in two rat mammary cancer cell lines: glucocorticoid and androgen receptors.

@article{Vignon1979HormonalRI,
  title={Hormonal regulation in two rat mammary cancer cell lines: glucocorticoid and androgen receptors.},
  author={Françoise Vignon and P. C. Y. Chan and Henri Rochefort},
  journal={Molecular and cellular endocrinology},
  year={1979},
  volume={13 2},
  pages={191-202}
}
We have studied the hormonal control of two continuous cell lines derived from rat-mammary tumors induced by two different carcinogens (dimethylbenzanthracene and N-nitrosomethylurea). The steroid receptors were assayed using charcoal or hydroxyapatite and the effect of different hormones on cell growth was evaluated by measuring total DNA and following the growth of transplanted cells in nude mice. Similar results were found for the two cell lines; they were unresponsive to estrogen since they… CONTINUE READING