Hormonal properties of norethisterone, 7α-methyl-norethisterone and their derivatives
@article{Schoonen2000HormonalPO, title={Hormonal properties of norethisterone, 7α-methyl-norethisterone and their derivatives}, author={W. Schoonen and G. Deckers and M. E. D. Gooijer and R. Ries and H. Kloosterboer}, journal={The Journal of Steroid Biochemistry and Molecular Biology}, year={2000}, volume={74}, pages={213-222} }
Norethisterone (NET) is a progestagenic compound with very weak androgenicity and estrogenicity. These low androgenic and estrogenic activities may be attributed to NET itself or induced by metabolites of NET. In order to improve the bioactivity of NET, the effects of a 7alpha-methyl substitution were studied. Thus this study has two objectives: first the comparison between biological activities of NET and 7alpha-methyl-NET (MeNET), and second the biological activity of tentative metabolites of… CONTINUE READING
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References
SHOWING 1-10 OF 25 REFERENCES
Norethisterone metabolites modulate the uteroglobin and progesterone receptor gene expression in prepubertal rabbits.
- Biology, Medicine
- Biology of reproduction
- 1995
- 15
- PDF
The metabolism of 19-nor contraceptive progestins modulates their biological activity at the neuroendocrine level.
- Biology, Medicine
- Journal of steroid biochemistry
- 1987
- 36
Intrinsic estrogenicity of some progestagenic drugs
- Chemistry, Medicine
- The Journal of Steroid Biochemistry and Molecular Biology
- 1992
- 53
The biological activity of 7 alpha-methyl-19-nortestosterone is not amplified in male reproductive tract as is that of testosterone.
- Biology, Medicine
- Endocrinology
- 1992
- 94
Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens
- Biology, Medicine
- The Journal of Steroid Biochemistry and Molecular Biology
- 1995
- 75
Endocrinological studies with (7 alpha, 17 alpha)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one (Org OD 14).
- Chemistry, Medicine
- Arzneimittel-Forschung
- 1984
- 68
A comparison of the potencies and activities of progestogens used in contraceptives.
- Medicine
- Contraception
- 1987
- 92
In vitro evaluation of estrogenic, estrogen antagonistic and progestagenic effects of a steroidal drug (Org OD-14) and its metabolites on human endometrium.
- Biology, Medicine
- Journal of steroid biochemistry
- 1990
- 114
In Vitro Metabolism of 7α-Methyl-19-Nortestosterone by Rat Liver, Prostate, and Epididymis
- Biology
- 1988
- 35
- PDF
Metabolic profiles of endogenous and ethynyl steroids in plasma and urine from women during administration of oral contraceptives.
- Chemistry, Medicine
- Journal of steroid biochemistry
- 1987
- 15