Hormonal properties of norethisterone, 7α-methyl-norethisterone and their derivatives

@article{Schoonen2000HormonalPO,
  title={Hormonal properties of norethisterone, 7$\alpha$-methyl-norethisterone and their derivatives},
  author={Willem G.E.J. Schoonen and Godefrides H Deckers and Marcel Evert De Gooijer and R de Ries and Helenius Jan Kloosterboer},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2000},
  volume={74},
  pages={213-222}
}
Norethisterone (NET) is a progestagenic compound with very weak androgenicity and estrogenicity. These low androgenic and estrogenic activities may be attributed to NET itself or induced by metabolites of NET. In order to improve the bioactivity of NET, the effects of a 7alpha-methyl substitution were studied. Thus this study has two objectives: first the comparison between biological activities of NET and 7alpha-methyl-NET (MeNET), and second the biological activity of tentative metabolites of… Expand
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