Hormonal prevention of breast cancer: mimicking the protective effect of pregnancy.

  title={Hormonal prevention of breast cancer: mimicking the protective effect of pregnancy.},
  author={Raphael C. Guzman and Joy Qi Yang and Lakshmanaswamy Rajkumar and Gudmundur Thordarson and Xiaoping Chen and S. B. Nandi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 5},
Full term pregnancy early in life is the most effective natural protection against breast cancer in women. Rats treated with chemical carcinogen are similarly protected by a previous pregnancy from mammary carcinogenesis. Proliferation and differentiation of the mammary gland does not explain this phenomenon, as shown by the relative ineffectiveness of perphenazine, a potent mitogenic and differentiating agent. Here, we show that short term treatment of nulliparous rats with pregnancy levels of… CONTINUE READING
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Guzman et al

  • B. T. Zhu, Conney, 19 A.H.Carcinogenesis, 1–27. Physiology
  • Proc. Natl. Acad. Sci. USA 96
  • 1999
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