Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history

@article{Flatt2005HormonalPA,
  title={Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history},
  author={T. Flatt and M. Tu and M. Tatar},
  journal={BioEssays},
  year={2005},
  volume={27}
}
Understanding how traits are integrated at the organismal level remains a fundamental problem at the interface of developmental and evolutionary biology. Hormones, regulatory signaling molecules that coordinate multiple developmental and physiological processes, are major determinants underlying phenotypic integration. The probably best example for this is the lipid‐like juvenile hormone (JH) in insects. Here we review the manifold effects of JH, the most versatile animal hormone, with an… Expand
Steroid hormone regulation of C. elegans and Drosophila aging and life history
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Life-History Evolution and the Genetics of Fitness Components in Drosophila melanogaster
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JUVENILE HORMONE AS A REGULATOR OF THE TRADE-OFF BETWEEN REPRODUCTION AND LIFE SPAN IN DROSOPHILA MELANOGASTER
  • T. Flatt, T. Kawecki
  • Biology, Medicine
  • Evolution; international journal of organic evolution
  • 2007
Abstract Trade-offs between reproduction and life span are ubiquitous, but little is known about their underlying mechanisms. Here we combine treatment with the juvenile hormone analog (JHa)Expand
Does Hormonal Pleiotropy Shape the Evolution of Performance and Life History Traits?
SYNOPSIS Hormonal pleiotropy occurs when a part of the endocrine system (e.g., hormone concentrations) influences the expression of two or more phenotypes. Although hormonal pleiotropy may haveExpand
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TLDR
It is argued that the MHC and other complex loci may be considered as life history gene complexes, with pleiotropic influences throughout the lifespan, and the population genetics that is involved provides a theoretical basis for great flexibility in hormonal regulation during life history evolution. Expand
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TLDR
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TLDR
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TLDR
Allatotropin-positive axons are found to be abundant in the adult brain and in the corpora cardiaca-corpus allatum complex but these neurons are less immunoreactive in the InR mutant genotype, suggesting that insulin signaling may affect JH synthesis through control of JH regulatory neuropeptides. Expand
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TLDR
This chapter reviews the actions of JH on the fat body, gonads, accessory glands, muscle, and nervous system of adult insects and emphasizes the importance of selecting insect systems on the basis of their optimal features for research, rather than historical precedent or economic importance. Expand
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TLDR
Alleles influenced phenotypic covariances among traits and the genetic covariance between developmental time and early fecundity attributed to alleles of Met was negative, indicating consistent pleiotropic effects among alleles on these traits. Expand
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TLDR
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TLDR
It is proposed that during sexual maturation of Drosophila, JH provides a signal to the ovary that leads to the production of several maternally inherited mRNAs. Expand
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TLDR
Application of commonly used JH inhibitors, such as precocene or fluvastatin, can reduce or inhibit JH synthesis in the CA and may thus be used to study the effects of JH deficiency on life span. Expand
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TLDR
A radiochemical assay was utilized to examine JH synthesis in vitro by the isolated corpus allatum as well as the regulation of this synthesis by brain extracts of wild-type and apterous mutant Drosophila melanogaster females during reproductive maturation. Expand
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