Hormonal modulation of sex differences in resistance to Leishmania major systemic infections.

Abstract

Differences in susceptibility to intravenously inoculated Leishmania major were observed in male and female mice of the BALB/cAnPt, DBA/2N, and DBA/2J strains and (BALB/cAnPt x DBA/2N)F1 hybrids. In all cases, males had significantly higher liver parasite burdens than females. Orchidectomy of BALB/c males resulted in a 20% decrease in the number of… (More)

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@article{Mock1988HormonalMO, title={Hormonal modulation of sex differences in resistance to Leishmania major systemic infections.}, author={Beverly A Mock and Carol A. Nacy}, journal={Infection and immunity}, year={1988}, volume={56 12}, pages={3316-9} }