Hormonal modulation of delta6 and delta5 desaturases: case of diabetes.

@article{Brenner2003HormonalMO,
  title={Hormonal modulation of delta6 and delta5 desaturases: case of diabetes.},
  author={Rodolfo R. Brenner},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={2003},
  volume={68 2},
  pages={151-62}
}
Animal biosynthesis of high polyunsaturated fatty acids from linoleic, alpha-linolenic and oleic acids is mainly modulated by the delta6 and delta5 desaturases through dietary and hormonal stimulated mechanisms. From hormones, only insulin activates both enzymes. In experimental diabetes mellitus type-1, the depressed delta6 desaturase is restored by insulin stimulation of the gene expression of its mRNA. However, cAMP or cycloheximide injection prevents this effect. The depression of delta6… CONTINUE READING

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