Hormonal management of migraine at menopause

  title={Hormonal management of migraine at menopause},
  author={Rossella Elena Nappi and Grazia Sances and Silvia Detaddei and Alessandra Ornati and Luca Chiovato and Franco Polatti},
  journal={Menopause International},
  pages={82 - 86}
In this review, we underline the importance of linking migraine to reproductive stages for optimal management of such a common disease across the lifespan of women. Menopause has a variable effect on migraine depending on individual vulnerability to neuroendocrine changes induced by estrogen fluctuations and on the length of menopausal transition. Indeed, an association between estrogen ‘milieu’ and attacks of migraine is strongly supported by several lines of evidence. During the perimenopause… 

Acute and Preventive Management of Migraine during Menstruation and Menopause

In women with perimenopausal migraine, hormonal treatments should aim at avoiding estrogen fluctuations, and the use of long-acting triptan and/or combined treatment with triptans and common analgesics is advisable.

Neuroendocrine aspects of migraine in women

  • R. NappiG. Nappi
  • Psychology, Biology
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2012
The role of endogenous estrogen at the level of brain circuitries which are involved in multiple cellular, neurochemical and neurophysiological processes associated with migraine will be summarized in the context of reproductive milestones.

Hormonal Manipulation Strategies in the Management of Menstrual Migraine and Other Hormonally Related Headaches

Practical strategies for hormonal manipulation in the management of migraine and other hormonally related headaches are presented.

Transdermal Hormonal Therapy in Perimenstrual Migraine: Why, When and How?

Clinical and preclinical data that are relevant for the role of estrogens in migraine are summarized and how estrogen modulation can be exploited positively to improve hormonal-related migraine is discussed.

Hormonally Related Headaches

Some research is needed to improve the knowledge about the use of estrogens and progestogens in women with hormonally related headaches and to identify the so-called estrogen-withdrawal headache.

Migraine and the menopausal transition

The purpose of this article is to review the literature to determine the effect of the menopausal transition on migraine headaches and to develop a rational treatment approach to these patients.

Migraines and perimenopause: helping women in midlife manage and treat migraine.

  • L. Hauser
  • Medicine
    Nursing for women's health
  • 2012
Diagnostic criteria for migraine with and without aura, the impact of fluctuating hormones in perimenopause on the experience of migraine and medication and nonmedication approaches to managing migraine are reviewed.


Migraine may bring a suffering phase in an individual's schedule yet it can be handled with the familiarity of some self-care remedies and by making simple modifications in the routine lifestyle, which may facilitate to pave the clear way to recovery and make things easier for migraine management.

Does menopause influence nocturnal awakening with headache?

It is concluded that menopausal status influences NAH and the women in perimenopause presented a high risk of having this complaint.

Sex-related differences in migraine

Sex-related differences in migraine epidemiology, symptoms, natural history and co-morbid disorders are reviewed and the many gender-related questions about treatment of migraine in women are evaluated.



Migraine in the menopause.

Many women with migraine, especially those with a history of menstrual migraine, experience an exacerbation as they approach menopause and restoration and stabilization of estrogen levels within the physiologic range are likely to diminish the migraine.

Menstruation, sex hormones, and migraine.

Migraine and the menopause

  • E. MacGregor
  • Medicine
    The journal of the British Menopause Society
  • 2006
It is concluded that migraine is not a contraindication for HRT but continuous-release transdermal estrogen, in the lowest effective dose, is recommended.

Headache and hormone replacement therapy in the postmenopausal woman

  • E. MacGregor
  • Medicine, Psychology
    Current treatment options in neurology
  • 2009
Perimenopausal women should routinely be asked about headache and migraine, so that they can be offered appropriate advice and therapy should regularly be evaluated, as hormonal triggers are self-limiting and abate after menopause.

Estrogens, progestins, and headache

There is no evidence that this risk is increased in migrainers who use OCs, and the frequency of migraine decreases with age, but tends either to regress or worsen during menopause.

Sex hormones and headache.

The role of sex hormones in headache

The treatment of menstrual migraine and migraine associated with menopause and the use of oral contraceptives is discussed, focusing on standard headache treatment and hormonal manipulation.

Postmenopausal hormone therapy and migraine headache.

In this cross-sectional study, current HT use was associated with higher rates of migraine headache than nonuse and clinical trials are needed to determine if HT increases the incidence of migraine in postmenopausal women.

Ovarian Hormones and Migraine Headache: Understanding Mechanisms and Pathogenesis—Part 2

A greater knowledge of ovarian hormones and their effect on migraine is essential to a greater understanding of the mechanisms and pathogenesis of migraine headache.