Hormonal control of gubernaculum development during testis descent: gubernaculum outgrowth in vitro requires both insulin-like factor and androgen.

@article{Emmen2000HormonalCO,
  title={Hormonal control of gubernaculum development during testis descent: gubernaculum outgrowth in vitro requires both insulin-like factor and androgen.},
  author={Judith M. A. Emmen and Anke McLuskey and Ibrahim M. Adham and Wolfgang Engel and J. Anton Grootegoed and Albert O. Brinkmann},
  journal={Endocrinology},
  year={2000},
  volume={141 12},
  pages={4720-7}
}
The gubernaculum connects the gonad to the inguinoscrotal region and is involved in testis descent. It rapidly develops in the male fetus, whereas development in the female fetus is lacking. Possible factors involved in gubernaculum development are androgens, anti-Müllerian hormone (AMH), and insulin-like factor (Insl3). Sexual dimorphism in gubernaculum development correlated with the mitotic activity of cells in the gubernacular bulbs from male and female fetuses. Androgen receptor expression… CONTINUE READING

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S Zimmermann, P Schottler, W Engel, IM Adham
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