Hormonal changes in the menopause transition.

@article{Burger2002HormonalCI,
  title={Hormonal changes in the menopause transition.},
  author={Henry G. Burger and Emma C Dudley and David M Robertson and Lorraine Dennerstein},
  journal={Recent progress in hormone research},
  year={2002},
  volume={57},
  pages={
          257-75
        }
}
The menopause is the permanent cessation of menstruation resulting from the loss of ovarian follicular activity. It is heralded by the menopausal transition, a period when the endocrine, biological, and clinical features of approaching menopause begin. A common initial marker is the onset of menstrual irregularity. The biology underlying the transition to menopause includes central neuroendocrine changes as well as changes within the ovary, the most striking of which is a profound decline in… 
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