Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study

@article{Pitchot2004HormonalAT,
  title={Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study},
  author={William Pitchot and Jacques Wauthy and Jean Jacques Legros and Marc Ansseau},
  journal={European Neuropsychopharmacology},
  year={2004},
  volume={14},
  pages={151-155}
}

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References

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Hormonal and temperature responses to the 5-HT1A receptor agonist flesinoxan in normal volunteers

TLDR
The results showed the role of 5-HT1A mechanisms in the PRL, ACTH, cortisol, GH, and temperature responses to flesinoxan and appeared a very promising serotonergic neuroendocrine probe.

Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers

TLDR
The data suggest that the growth hormone and hypothermic responses to buspirone in humans are mediated by 5-HT1A receptors, but an explanation founded on pharmacokinetic factors cannot presently be excluded.

Effect of pindolol on thel-5-htp-induced increase in plasma prolactin and cortisol concentrations in man

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It is suggested that thel-5-HTP-induced increase in PRL but not cortisol secretion requires 5-HT1A receptor activation, and the implication of this synergistic effect for interpretation of neuroendocrine studies involving the serotonergic system in man is discussed.

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Observations provide confirmatory evidence of a post beta-adrenoceptor blockade withdrawal syndrome which differs between the two drugs studied and this may reflect the properties of the drugs, in particular the PAA of bopindolol.

Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans.

TLDR
The data suggest that the PRL response to buspirone challenge reflects the responsivity of 5-HT1a receptors in the limbic-hypothalamus in humans and that reduced sensitivity of these receptors is associated with an important component of impulsive aggressive behaviors in personality disorder patients.

Comparative effects of serotonergic agonists withvarying efficacy at the 5-HT1A receptor on core body temperature: modification by the selective 5-HT1A receptor antagonist WAY 100635

TLDR
The utility of hypothermia as a simple, robust in-vivo probe of 5-HT1A receptor function is confirmed and this paradigm, which was enhanced by use of specific antagonists such as WAY 100635, may prove useful for the detection and characterization of novel 5- HT1Areceptor ligands.

Pindolol decreases prolactin and growth hormone responses to intravenousL-tryptophan

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The effects of pindolol on the prolactin (PRL) and growth hormone (GH) responses to intravenous tryptophan (LTP) were studied and it is suggested that the intrinsic sympathomimetic actions of pINDolol might also be involved in the attenuation of the endocrine responses to LTP.