Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study

  title={Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study},
  author={William Pitchot and Jacques Wauthy and Jean Jacques Legros and Marc Ansseau},
  journal={European Neuropsychopharmacology},

5-Hydroxytryptamine 1 A Receptors , Major Depression , and Suicidal Behavior

The present study tends to confirm the role of 5-HT and more specifically 5- HT1A receptors in the biology of suicidal behavior in major depression.

Occupancy of Agonist Drugs at the 5-HT1A Receptor

It is concluded that 5-HT1A receptor agonists produce detectable occupancy only at higher doses that would produce unacceptable levels of side effects in man, although lower doses are sufficient to produce pharmacological effects.

The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers

The results of this study suggest that escitalopram might exert its therapeutic effect in women in part through correction of a flattened diurnal cortisol rhythm.

Stress-Induced Hyperthermia, the Serotonin System and Anxiety

The present review aims to discuss the acute and chronic effects of 5-HT ligands on the SIH response, and theSIH response in genetically modified mice that lack or overexpress specific serotonergic receptor subtypes or the serotonin transporter will be summarized.

The effect of a 5‐HT1A receptor agonist on striatal dopamine release

The results suggest that the anticataleptic effect of 5‐HT1A receptors agonists is not mediated by striatal dopamine release, and indicates a need for further research with other suitable 5‐ HT1A receptor agonists.

Activation of 5-HT1A Receptors in the Hypothalamic Paraventricular Nuclei Negatively Regulates Cytochrome P450 Expression and Activity in Rat Liver

The obtained results indicated that 5-HT1A but not the 5- HT1B/D or5-HT2 receptors in the PVN are engaged in the negative neuroendocrine regulation of cytochrome P450 via the stimulation of hypothalamic somatostatin secretion and in the decreases in the serum growth hormone and corticosterone concentrations.



Hormonal and temperature responses to the 5-HT1A receptor agonist flesinoxan in normal volunteers

The results showed the role of 5-HT1A mechanisms in the PRL, ACTH, cortisol, GH, and temperature responses to flesinoxan and appeared a very promising serotonergic neuroendocrine probe.

Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers

The data suggest that the growth hormone and hypothermic responses to buspirone in humans are mediated by 5-HT1A receptors, but an explanation founded on pharmacokinetic factors cannot presently be excluded.

Effect of pindolol on thel-5-htp-induced increase in plasma prolactin and cortisol concentrations in man

It is suggested that thel-5-HTP-induced increase in PRL but not cortisol secretion requires 5-HT1A receptor activation, and the implication of this synergistic effect for interpretation of neuroendocrine studies involving the serotonergic system in man is discussed.

Withdrawal phenomena after atenolol and bopindolol: hormonal changes in normal volunteers.

Observations provide confirmatory evidence of a post beta-adrenoceptor blockade withdrawal syndrome which differs between the two drugs studied and this may reflect the properties of the drugs, in particular the PAA of bopindolol.

Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans.

The data suggest that the PRL response to buspirone challenge reflects the responsivity of 5-HT1a receptors in the limbic-hypothalamus in humans and that reduced sensitivity of these receptors is associated with an important component of impulsive aggressive behaviors in personality disorder patients.

Comparative effects of serotonergic agonists withvarying efficacy at the 5-HT1A receptor on core body temperature: modification by the selective 5-HT1A receptor antagonist WAY 100635

The utility of hypothermia as a simple, robust in-vivo probe of 5-HT1A receptor function is confirmed and this paradigm, which was enhanced by use of specific antagonists such as WAY 100635, may prove useful for the detection and characterization of novel 5- HT1Areceptor ligands.

Pindolol decreases prolactin and growth hormone responses to intravenousL-tryptophan

The effects of pindolol on the prolactin (PRL) and growth hormone (GH) responses to intravenous tryptophan (LTP) were studied and it is suggested that the intrinsic sympathomimetic actions of pINDolol might also be involved in the attenuation of the endocrine responses to LTP.