Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study

@article{Pitchot2004HormonalAT,
  title={Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study},
  author={William Pitchot and Jacques Wauthy and Jean Jacques Legros and Marc Ansseau},
  journal={European Neuropsychopharmacology},
  year={2004},
  volume={14},
  pages={151-155}
}
RATIONALE Flesinoxan is a highly potent and selective 5-HT1A agonist. In a recent study, in normal volunteers, flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. OBJECTIVES In order to better define the role of 5-HT receptor subtypes in response to flesinoxan, we assessed the influence of 5-HT1A and 5-HT2 antagonists on hormonal and temperature responses to… Expand
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