Hormonal and Metabolite Regulation of Hepatic Glucokinase.

  title={Hormonal and Metabolite Regulation of Hepatic Glucokinase.},
  author={Loranne Agius},
  journal={Annual review of nutrition},
Liver glucose metabolism is dependent on glucokinase activity. Glucokinase expression is transcriptionally regulated by hormones and metabolites of glucose, and glucokinase activity is dependent on reversible binding of glucokinase to a specific inhibitor protein, glucokinase regulatory protein (GKRP), and to other binding proteins such as 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK2/FBP2), which functions as an activator. Glucokinase is inhibited in the postabsorptive state by… CONTINUE READING