Hormonal Therapy of Prostatic Cancer

@article{Scott1980HormonalTO,
  title={Hormonal Therapy of Prostatic Cancer},
  author={William Wallace Scott and M. Menon and Patrick C. Walsh},
  journal={Cancer},
  year={1980},
  volume={45}
}
The principle goal of hormonal therapy in the treatment of prostatic cancer, as Huggins suggested in 1941, is the suppression of androgenic stimuli. Consequently, the treatment of advanced prostatic cancer has consisted of orchiectomy, estrogen administration, antiandrogen therapy, adrenalectomy or hypophysectomy, or a combination of some of these. Although the three VACURG studies are subject to several valid criticisms, they provide the best available information to date. In summary, these… Expand
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TLDR
Preliminary studies with aminoglutethimide indicate that it can produce biochemical and clinical effects similar to those of pituitary ablation and may be associated with relief of pain in patients who had been on stilboestrol. Expand
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A limited role for aminoglutethimide in the management of prostatic carcinoma is suggested and a fall in plasma testosterone beyond that achieved by oestrogens was not observed. Expand
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A study of urinary hormones in a series of patients with prostatic cancer, before and after castration, in the hope of clarifying secretion-excretion relations. Expand
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It is concluded that suppression of plasma testosterone levels observed during chlorotrianisene therapy is the result of a direct effect on the testis and that this agent may be of value in studies of gonadotrophin physiology. Expand
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Evidence is presented that significant improvement often occurs in the clinical condition of patients with far advanced cancer of the prostate after they have been subjected to castration and this work provides a new concept of prostatic carcinoma. Expand
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TLDR
For the past eight years the physician has been confronted with problems concerning the selection of the form of endocrine modification most efficacious for the particular needs of the patient, the designation of the most opportune time to institute therapy and the choice of secondary therapy once relapse has occurred. Expand
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TLDR
The overall recommendation at present is that patients with prostatic cancer should not be treated until their symptoms require relief, and at that time it is recommended starting treatment with 1.0 mg DES daily. Expand
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It is demonstrated that a marked rise in acid phosphatase in serum is associated with the appearance or spread of roentgenologically demonstrable skeletal metastases and implies dissemination of the primary tumor and thus is of unfavorable prognostic significance. Expand
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TLDR
Nuclear chromatin of prostate, but not other tissues which are insensitive to androgen, contains an androgen receptor which can selectively retain dihydrotestosterone (DHT, 5α-androstane-17β-ol-3-one)—the most potent endogenous androgen for the growth of ventral prostate of rat13,14. Expand
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It was showed that early endocrine treatment of patients with advanced prostatic cancer did not increase overall survival when compared to initial treatment with placebo alone, and diethylstilbestrol, when given in a dose of 5.0 mg/day, was associated with an increased incidence of cardiovascular deaths. Expand
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