Hormonal Regulation of GnRH and LHβ mRNA Expression in Cultured Rat Granulosa Cells

@article{Litichever2009HormonalRO,
  title={Hormonal Regulation of GnRH and LHβ mRNA Expression in Cultured Rat Granulosa Cells},
  author={Naomi Litichever and Eran Gershon and Nava Dekel and Yitzhak Koch},
  journal={Journal of Molecular Neuroscience},
  year={2009},
  volume={39},
  pages={78-85}
}
We have recently demonstrated that the rat ovary expresses LHβ, FSHβ, and the common alpha subunit mRNA. In the present report, we studied the regulation of LHβ and of gonadotropin-releasing hormone (GnRH) mRNA expression in granulosa cells that were isolated from immature rats treated with either estrogen or pregnant mare serum gonadotropin (PMSG). In both cell types, GnRH agonist treatment resulted in a decrease in LHβ mRNA expression. However, only in cells derived from PMSG-treated rats… CONTINUE READING