Hormonal Control of Alveolar Development and Its Implications for Breast Carcinogenesis

@article{Brisken2004HormonalCO,
  title={Hormonal Control of Alveolar Development and Its Implications for Breast Carcinogenesis},
  author={Cathrin Brisken},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2004},
  volume={7},
  pages={39-48}
}
  • C. Brisken
  • Published 2004
  • Medicine
  • Journal of Mammary Gland Biology and Neoplasia
During puberty and pregnancy, the breast undergoes major restructuring in order to produce a structure that can secrete and eject copious amounts of milk. By analogy to other branched organs such as the lung or the salivary gland, a large increase in surface area of the specialized epithelium is achieved through repeated ramifications of a system of ducts and alveoli arising from the nipple. In the breast, this process culminates in the appearance of thousands of alveoli or acini, saccular… 

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References

SHOWING 1-10 OF 63 REFERENCES

Impact of progesterone receptor on cell-fate decisions during mammary gland development.

Strong evidence is provided to indicate that PR signaling may be of paramount importance for appropriate cell-fate decisions during normal mammary development, and also that this requires a regulated expression of the two isoforms.

Progesterone receptors in the mouse mammary duct: distribution and developmental regulation.

In the mammary epithelium of prepubertal mice, high levels of progesterone receptor mRNA and protein are present in the actively growing end buds and ductal branches as well as in the mature duct, and Cytoplasmic and nuclear immunostaining were observed; interestingly, this staining occurred in separate cells that were in close proximity to each other.

A paracrine role for the epithelial progesterone receptor in mammary gland development.

Together, these results indicate that progesterone acts by a paracrine mechanism on a subset of mammary epithelial cells to allow for alveolar growth and that expression of the PR is not required in all the cells of the Mammary epithelium in order forAlveolar development to proceed normally.

Cellular Turnover in the Mammary Gland Is Correlated with Systemic Levels of Progesterone and Not 17β-Estradiol During the Estrous Cycle1

It is proposed that the cyclical turnover of epithelial cells within the adult mammary tissue is a sum of spatial and functional coordination of hormonal and matrix regulatory factors.

Mammary gland development is mediated by both stromal and epithelial progesterone receptors.

This study suggests that the regulation of mammary gland development by steroid hormones is mediated by distinct effects of the stromal and epithelial PR and differential growth factor expression.

Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland.

It is demonstrated that fibroblast growth factor signalling is necessary for pregnancy dependent lobuloalveolar development of the mammary gland.

Effect of oestradiol on progesterone receptors in normal mammary glands and its relationship with lactation.

Mammary glands of lactating mice, either intact or ovariectomized, do not contain detectable amounts of progesterone receptors and this lack of receptors persists also in tissues of animals treated

Parathyroid Hormone-Related Protein: A Developmental Regulatory Molecule Necessary for Mammary Gland Development

The current knowledge of the mechanisms underlying PTHrP actions during normal mammary development and in breast cancer are discussed.

Estrogen receptors α and β in the rodent mammary gland

It was found that both estrogen receptors, ERα and ERβ, are expressed in the rat mammary gland but the presence and cellular distribution of the two receptors are distinct.
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