Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development

@article{Cunha2004HormonalCA,
  title={Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development},
  author={Gerald R. Cunha and Will A. Ricke and Axel A. Thomson and Paul C. Marker and Takeshi Kurita},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2004},
  volume={92},
  pages={221-236}
}
This review on normal and neoplastic growth of the prostate emphasizes the importance of epithelial-mesenchymal/stromal interactions. Accordingly, during prostatic development urogenital sinus mesenchyme (a) specifies prostatic epithelial identity, (b) induces epithelial bud formation, (c) elicits prostatic bud growth and regulates ductal branching, (d) promotes differentiation of a secretory epithelium, and (e) specifies the types of secretory proteins expressed. In reciprocal fashion… CONTINUE READING
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