Hormesis and aging
Healthy aging may be achieved through mild and periodic but not severe or chronic physical and mental challenges and by the use of nutritional hormesis incorporating mild stress-inducing molecules called hormetins.
Hormetic Interventions in Aging
Healthy aging may be achieved by hormesis through mild and periodic, but not severe or chronic, physical and mental challenges and by the use of dietary hormesis incorporating mild stress-inducing molecules called hormetins.
Hormesis as a Mechanism for the Anti-Aging Effects of Calorie Restriction
periodic modulation of dietary input as a hormetic intervention may be applicable to human beings for slowing down aging.
Hormesis as a Pro-Healthy Aging Intervention in Human Beings?
- Biology, MedicineDose-response : a publication of International Hormesis Society
Moderate-intensity exercise, weight management and healthy diet ameliorate diseases of aging to increase lifespan and this could involve hormesis, and whether it might apply to humans is discussed.
Hormesis in Health and Disease: Molecular Mechanisms
- Medicine, Biology
This review will elucidate the hormesis’ definition, mechanisms and pathways, and also how hormesis impacts in human health and lifespan.
Heat Stress and Hormetin-Induced Hormesis in Human Cells: Effects on Aging, Wound Healing, Angiogenesis, and Differentiation
- BiologyDose-response : a publication of International Hormesis Society
Novel hormetic effects of mild heat stress on improving the wound healing capacity of skin fibroblasts and on enhancing the angiogenic ability of endothelial cells are observed, supporting the view that mild stress-induced hormesis can be applied for the modulation, intervention and prevention of aging and age-related impairments.
The Molecular Mechanisms of Adaptive Response Related to Environmental Stress
- BiologyInternational journal of molecular sciences
Findings provide evidence that hormesis is a toxicological event, occurring at low exposure doses to environmental stressors, having the benefit for the maintenance of a healthy status.
Primary Stress Response Pathways for Preconditioning and Physiological Hormesis
- BiologyThe Science of Hormesis in Health and Longevity
ER stress and hormetic regulation of the aging process
- BiologyAgeing Research Reviews
SHOWING 1-10 OF 232 REFERENCES
Aging intervention, prevention, and therapy through hormesis.
- MedicineThe journals of gerontology. Series A, Biological sciences and medical sciences
Hormesis appears to be a promising and effective approach for modulating aging, for preventing or delaying the onset of age-related diseases, and for improving quality of life in old age.
Hormetic Prevention of Molecular Damage during Cellular Aging of Human Skin Fibroblasts and Keratinocytes
- BiologyAnnals of the New York Academy of Sciences
RMHS at 41°C, for 1 h twice a week, increased the basal levels of various chaperones, reduced the accumulation of oxidatively and glycoxidatively damaged proteins, stimulated proteasomal activities for the degradation of abnormal proteins, improved cellular resistance to ethanol, hydrogen peroxide, and UV‐B rays, and increased the phosphorylation‐mediated activities of various stress kinases.
Stress Resistance by Caloric Restriction for Longevity
- MedicineAnnals of the New York Academy of Sciences
The life‐prolonging action of caloric restriction (CR) seems to offer an excellent opportunity for investigating the interrelationship between stress and the aging process, and can be viewed as “nutritional stress,” because the organism's reduced caloric intake seems to be a stimulatory metabolic response for survivability.
Exercise and hormesis: oxidative stress-related adaptation for successful aging
It is suggested that exercise-induced ROS production plays a role in the induction of antioxidants, DNA repair and protein degrading enzymes, resulting in decreases in the incidence of oxidative stress-related diseases and retardation of the aging process.
Theories of biological aging: Genes, proteins, and free radicals
- BiologyFree radical research
A unified theory of biological aging in terms of failure of homeodynamics comprising of MRS, and involving genes, milieu and chance, is acquiring a definitive shape and wider acceptance and establishes the basis for testing and developing effective means of intervention, prevention and modulation of aging.
Hormesis/preconditioning mechanisms, the nervous system and aging
- BiologyAgeing Research Reviews
Modulating cellular aging in vitro: Hormetic effects of repeated mild heat stress on protein oxidation and glycation
- BiologyExperimental Gerontology
Longevity and aging: beneficial effects ofexposure to mild stress
Exposing organisms to amild, sublethal stress, inducing a stress response, may help them to live longer, and studies conducted so far show that they may involve metabolic regulation and stress protein(hsps) induction.
Understanding and Modulating Ageing
- BiologyIUBMB life
A combination of molecular, physiological and psychological modulatory approaches can realize “healthy ageing” as an achievable goal in the not‐so‐distant future.
Hormetic action of mild heat stress decreases the inducibility of protein oxidation and glycoxidation in human fibroblasts
Testing whether RMHS can reduce the accumulation of heavily damaged proteins, such as oxidized and glycoxidized proteins involved in the development of many pathological consequences of aging found modulation of the level of damaged proteins is most likely related to the beneficial effects of hormesis resulting from exposure to mild stress.