Hormesis in aging

@article{Rattan2008HormesisIA,
  title={Hormesis in aging},
  author={Suresh I. S. Rattan},
  journal={Ageing Research Reviews},
  year={2008},
  volume={7},
  pages={63-78}
}
  • S. Rattan
  • Published 31 January 2008
  • Biology
  • Ageing Research Reviews

Tables from this paper

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References

SHOWING 1-10 OF 232 REFERENCES

Aging intervention, prevention, and therapy through hormesis.

  • S. Rattan
  • Medicine
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2004
TLDR
Hormesis appears to be a promising and effective approach for modulating aging, for preventing or delaying the onset of age-related diseases, and for improving quality of life in old age.

Hormetic Prevention of Molecular Damage during Cellular Aging of Human Skin Fibroblasts and Keratinocytes

TLDR
RMHS at 41°C, for 1 h twice a week, increased the basal levels of various chaperones, reduced the accumulation of oxidatively and glycoxidatively damaged proteins, stimulated proteasomal activities for the degradation of abnormal proteins, improved cellular resistance to ethanol, hydrogen peroxide, and UV‐B rays, and increased the phosphorylation‐mediated activities of various stress kinases.

Stress Resistance by Caloric Restriction for Longevity

  • B. YuH. Chung
  • Medicine
    Annals of the New York Academy of Sciences
  • 2001
TLDR
The life‐prolonging action of caloric restriction (CR) seems to offer an excellent opportunity for investigating the interrelationship between stress and the aging process, and can be viewed as “nutritional stress,” because the organism's reduced caloric intake seems to be a stimulatory metabolic response for survivability.

Exercise and hormesis: oxidative stress-related adaptation for successful aging

TLDR
It is suggested that exercise-induced ROS production plays a role in the induction of antioxidants, DNA repair and protein degrading enzymes, resulting in decreases in the incidence of oxidative stress-related diseases and retardation of the aging process.

Theories of biological aging: Genes, proteins, and free radicals

TLDR
A unified theory of biological aging in terms of failure of homeodynamics comprising of MRS, and involving genes, milieu and chance, is acquiring a definitive shape and wider acceptance and establishes the basis for testing and developing effective means of intervention, prevention and modulation of aging.

Longevity and aging: beneficial effects ofexposure to mild stress

TLDR
Exposing organisms to amild, sublethal stress, inducing a stress response, may help them to live longer, and studies conducted so far show that they may involve metabolic regulation and stress protein(hsps) induction.

Understanding and Modulating Ageing

TLDR
A combination of molecular, physiological and psychological modulatory approaches can realize “healthy ageing” as an achievable goal in the not‐so‐distant future.

Hormetic action of mild heat stress decreases the inducibility of protein oxidation and glycoxidation in human fibroblasts

TLDR
Testing whether RMHS can reduce the accumulation of heavily damaged proteins, such as oxidized and glycoxidized proteins involved in the development of many pathological consequences of aging found modulation of the level of damaged proteins is most likely related to the beneficial effects of hormesis resulting from exposure to mild stress.
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