Hormesis can and Does Work in Humans

  title={Hormesis can and Does Work in Humans},
  author={Suresh I. S. Rattan and Dino Demirovic},
If we accept the validity of the general concept of physiological hormesis as being the phenomenon of achieving health beneficial effects by exposure to mild stress, then hormesis is being applied already and successfully to humans. The evidence for this is the well-demonstrated health benefits of regular and moderate exercise. Mild stress-induced activation of one or more intracellular pathways of stress response are central to this. Experimental studies performed on human cells in culture… 

Tables from this paper

Hormesis for Healthy Aging

  • S. Rattan
  • Biology, Medicine
    The Science of Hormesis in Health and Longevity
  • 2019

Testing the hormetic nature of homeopathic interventions through stress response pathways

In order to claim homeopathy as being hormetic, it is essential that, in addition to the hormetic biphasic dose response, homeopathic remedies should fulfill one or more molecular criteria.

Hormetins as Novel Components of Cosmeceuticals and Aging Interventions

A promising strategy for maintaining a healthy and youthful phenotype during aging is that of mild stress-induced beneficial hormesis, and polyphenols, flavonoids and other components from spices, algae and other sources are potential hormetins that may act via hormesis.

“Is Hormesis Applicable as a Pro-Healthy Aging Intervention in Mammals and Human Beings, and How?”

All authors have provided the same answer to the question “Is hormesis applicable as a pro-healthy aging intervention in mammals and human beings?” and this answer is “Yes”.

Hormesis-Based Anti-Aging Products: A Case Study of a Novel Cosmetic

This extract from the roots of the Chinese herb Sanchi has significant positive effects against facial wrinkles and other symptoms of facial skin aging as tested clinically, which may be due to its hormetic mode of action by stress-induced synthesis of chaperones involved in protein repair and removal of abnormal proteins.

Dissection of the Hormetic Curve: Analysis of Components and Mechanisms

  • V. Lushchak
  • Medicine
    Dose-response : a publication of International Hormesis Society
  • 2014
The problems limiting progress in the development of the hormesis concept such as low reproducibility and predictability may be solved, at least partly, by deciphering the molecular mechanisms underlying the hormetic dose-effect relationship.

Balneotherapy, Immune System, and Stress Response: A Hormetic Strategy?

Results from several investigations suggest that the beneficial effects of balneotherapy and hydrotherapy are consistent with the concept of hormesis, and thus support a role for hormesis in hydrothermal treatments.

Molecular gerontology: from homeodynamics to hormesis.

  • S. Rattan
  • Medicine
    Current pharmaceutical design
  • 2014
A promising strategy in biogerontology is to slow down aging and to extend healthspan by hormetin-mediated hormesis, which is potentially effective aging modulators.



Hormesis in aging

Hormetic effects of regular exercise in aging: correlation with oxidative stress.

It is suggested that moderate regular exercise attenuates oxidative stress and appears to manifest a hormesis-like effect in nonmuscular tissues, constituting beneficial mechanisms of exercise by adaptively upregulating various antioxidant mechanisms, including antioxidative and repair-degradation enzymes for damaged molecules.

Heat Stress and Hormetin-Induced Hormesis in Human Cells: Effects on Aging, Wound Healing, Angiogenesis, and Differentiation

Novel hormetic effects of mild heat stress on improving the wound healing capacity of skin fibroblasts and on enhancing the angiogenic ability of endothelial cells are observed, supporting the view that mild stress-induced hormesis can be applied for the modulation, intervention and prevention of aging and age-related impairments.

Hormetic Modulation of Aging in Human Cells

An experimental model system that has been used in testing and applying hormesis as a modulator of aging is the so-called Hayflick system of cellular aging in vitro, which involves the study of normal diploid cells in culture.

Acute exercise and oxidative stress: a 30 year history

A comprehensive summary of original investigations focused on exercise-induced oxidative stress is presented to provide the reader with a well-documented account of the research done within this area of science over the past 30 years.


The molecular mechanism and the state of the HS response as well as the role of specific HSPs during ageing are described, and the possibility of hormetic modulation of ageing and longevity by repeated mild stress is discussed.

Increased molecular damage and heterogeneity as the basis of aging

Mild stress-induced hormesis by physical, biological and nutritional methods, including hormetins, represents a promising strategy for achieving healthy aging and for preventing age-related diseases.

Theories of biological aging: Genes, proteins, and free radicals

A unified theory of biological aging in terms of failure of homeodynamics comprising of MRS, and involving genes, milieu and chance, is acquiring a definitive shape and wider acceptance and establishes the basis for testing and developing effective means of intervention, prevention and modulation of aging.