Hormesis and debilitation effects in stress experiments using the nematode worm Caenorhabditis elegans: the model of balance between cell damage and HSP levels.

@article{Butov2001HormesisAD,
  title={Hormesis and debilitation effects in stress experiments using the nematode worm Caenorhabditis elegans: the model of balance between cell damage and HSP levels.},
  author={Alexander A. Butov and Thomas Johnson and Jim Cypser and Igor A. Sannikov and Michael Volkov and Mary Sehl and A. D. Yashin},
  journal={Experimental gerontology},
  year={2001},
  volume={37 1},
  pages={57-66}
}
In this article, we discuss mechanisms responsible for the effects of heat treatment on increasing subsequent survival in the nematode worm Caenorhabditis elegans. We assume that the balance between damage associated with exposure to thermal stress and the level of heat shock proteins produced plays a key role in forming the age-pattern of mortality and survival in stress experiments. We propose a stochastic model of stress, which describes the accumulation of damage in the cells of the worm as… CONTINUE READING

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