Hormesis: the dose-response revolution.

@article{Calabrese2003HormesisTD,
  title={Hormesis: the dose-response revolution.},
  author={Edward J. Calabrese and Linda A. Baldwin},
  journal={Annual review of pharmacology and toxicology},
  year={2003},
  volume={43},
  pages={175-97}
}
Hormesis, a dose-response relationship phenomenon characterized by low-dose stimulation and high-dose inhibition, has been frequently observed in properly designed studies and is broadly generalizable as being independent of chemical/physical agent, biological model, and endpoint measured. This under-recognized and -appreciated concept has the potential to profoundly change toxicology and its related disciplines with respect to study design, animal model selection, endpoint selection, risk… CONTINUE READING

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