Horizontally acquired DAP pathway as a unit of self-regulation.

@article{Sun2011HorizontallyAD,
  title={Horizontally acquired DAP pathway as a unit of self-regulation.},
  author={Guiling Sun and J Huang},
  journal={Journal of evolutionary biology},
  year={2011},
  volume={24 3},
  pages={587-95}
}
In this study, we report the acquisition of the diaminopimelic acid (DAP) pathway of lysine biosynthesis in choanoflagellate Monosiga brevicollis and investigate how this pathway is incorporated and regulated in the established metabolic network. Our data show that all major genes related to the DAP pathway in Monosiga were acquired from bacteria and algae. Although an endogenous lysC exists in Monosiga, the newly acquired lysC is fused to lysA and used specifically for lysine biosynthesis. In… CONTINUE READING

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