Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo.

@article{Goldenberg2012HorizontalTA,
  title={Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo.},
  author={David M. Goldenberg and David Zagzag and Kerstin Heselmeyer-Haddad and Lissa Y Berroa Garcia and Thomas Ried and Meiyu Loo and Chien-Hsing Ken Chang and David V. Gold},
  journal={International journal of cancer},
  year={2012},
  volume={131 1},
  pages={
          49-58
        }
}
Cell fusion in vitro has been used to study cancer, gene mapping and regulation, and the production of antibodies via hybridomas. However, in-vivo heterosynkaryon formation by cell-cell fusion has received less attention. This investigation describes the spontaneous fusion of a human glioblastoma with normal hamster cells after xenogeneic transplantation, resulting in malignant cells that express both human and hamster genes and gene products, and retention of glioblastoma traits with an… CONTINUE READING
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CITES RESULTS & BACKGROUND
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References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

Über die Progression der Malignität: Eine Hypothese

  • Klinische Wochenschrift
  • 1968
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Biological implications of cell fusion

  • Nature Reviews Molecular Cell Biology
  • 2005
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

a unifying explanation of metastasis

JM Pawelek, Chakrabarty AK. Fusion of tumor cells with bone marrow-derived cells
  • Nat Rev Cancer 2008;8: 377–86. C an ce r C el l B io lo gy Goldenberg et al. 57 Int. J. Cancer: 131, 49–58
  • 2012
VIEW 1 EXCERPT

Malignant cells facilitate lung metastasis by bringing their own soil.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2010
VIEW 1 EXCERPT

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