Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis.

  title={Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis.},
  author={Vania Rosas-Magallanes and Patrick Deschavanne and Llu{\'i}s Quintana-Murci and Roland Brosch and B. Gicquel and Olivier Neyrolles},
  journal={Molecular biology and evolution},
  volume={23 6},
The contribution of interspecies horizontal gene transfer (HGT) to the evolution and virulence of Mycobacterium tuberculosis, the agent of tuberculosis in humans, has been barely investigated. Here we have studied the evolutionary history of the M. tuberculosis Rv0986-8 virulence operon recently identified, through functional genomics approaches, as playing an important role in parasitism of host phagocytic cells. We showed that among actinobacteria, this operon is specific to the M… CONTINUE READING
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Associate Editor Accepted March 1

  • William Martin
  • Horizontal Gene Transfer in M. tuberculosis
  • 2006

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