• Corpus ID: 2879007

Horizontal gene transfer may explain variation in {\theta}s

  title={Horizontal gene transfer may explain variation in \{\theta\}s},
  author={Rohan Maddamsetti and Philip J. Hatcher and St{\'e}phane Cruveiller and Claudine M'edigue and Jeffrey E. Barrick and Richard E. Lenski},
  journal={arXiv: Populations and Evolution},
Martincorena et al. estimated synonymous diversity ({\theta}s = 2N{\mu}) across 2,930 orthologous gene alignments from 34 Escherichia coli genomes, and found substantial variation among genes in the density of synonymous polymorphisms. They argue that this pattern reflects variation in the mutation rate per nucleotide ({\mu}) among genes. However, the effective population size (N) is not necessarily constant across the genome. In particular, different genes may have different histories of… 

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