Horizontal gene transfer in human pathogens

@article{Juhas2015HorizontalGT,
  title={Horizontal gene transfer in human pathogens},
  author={Mario Juhas},
  journal={Critical Reviews in Microbiology},
  year={2015},
  volume={41},
  pages={101 - 108}
}
  • M. Juhas
  • Published 2 January 2015
  • Biology
  • Critical Reviews in Microbiology
Abstract Horizontal gene transfer has a tremendous impact on the genome plasticity, adaptation and evolution of bacteria. Horizontally transferred mobile genetic elements are involved in the dissemination of antibiotic resistance and virulence genes, thus contributing to the emergence of novel “superbugs”. This review provides update on various mechanisms of horizontal gene transfer and examines how horizontal gene transfer contributes to the evolution of pathogenic bacteria. Special focus is… 

Horizontal transfer of antibiotic resistance genes in clinical environments.

It is highlighted how 11 of the top 12 priority antibiotic-resistant pathogens are known or predicted to be naturally transformable, raising the possibility that this mechanism of HGT makes significant contributions to the spread of ARGs.

Genomic Islands and the Evolution of Multidrug-Resistant Bacteria

  • M. Juhas
  • Biology
    Horizontal Gene Transfer
  • 2019
This review provides an update on the investigation of genomic islands with particular emphasis on their role in the evolution of multidrug-resistant bacteria.

Models for Gut-Mediated Horizontal Gene Transfer by Bacterial Plasmid Conjugation

This review discusses key studies on the current models for in silico, in vitro, and in vivo modeling of bacterial conjugation, and their ability to reflect the gut of animals and uses computational and in vitro models that may approximate aspects of the gut, as well as animal models that represent in vivo conditions to a greater extent.

Comprehensive analysis of horizontal gene transfer among multidrug-resistant bacterial pathogens in a single hospital

This work surveyed a large number of bacterial genomes sampled from infections at a single hospital in a systematic and unbiased manner, and was able to track the independent transfer of MGEs over time, expanding the understanding of HGT in healthcare settings and can inform efforts to limit the spread of drug-resistant pathogens in hospitals.

Systematic detection of horizontal gene transfer across genera among multidrug-resistant bacteria in a single hospital

This work screened the genomes of 2173 bacterial isolates from healthcare-associated infections from a single hospital over 18 months, and identified identical nucleotide regions in bacteria belonging to distinct genera and identified two instances of likely plasmid transfer within individual patients.

Horizontal Gene Transfer and Its Association with Antibiotic Resistance in the Genus Aeromonas spp.

The evolution of multidrug resistant bacteria to the most diverse antimicrobials known so far pose a serious problem to global public health and implications of the emergence of resistance in Aeromonas spp.

Interference plasmids and their use in combating bacterial resistance

  • A. Zhivich
  • Medicine
    Microbiology Independent Research journal
  • 2019
The author examines new possibilities to use the mechanism of horizontal gene transfer for the developing of novel approaches to fight pathogenic bacteria through incompatibility-based plasmid curing systems.

Staphylococcus aureus competence genes: mapping of the SigH, ComK1 and ComK2 regulons by transcriptome sequencing

Staphylococcus aureus is a major human pathogen. Hospital infections caused by methicillin‐resistant strains (MRSA), which have acquired resistance to a broad spectrum of antibiotics through
...

References

SHOWING 1-10 OF 111 REFERENCES

The role of horizontal gene transfer in Staphylococcus aureus host adaptation

The data suggest that the common pathogenic clone associated with small ruminants originated in humans but has since adapted to its adopted host through a combination of allelic diversification, gene loss and acquisition of mobile genetic elements.

Genomic islands: tools of bacterial horizontal gene transfer and evolution

Genomic islands play a crucial role in the evolution of a broad spectrum of bacteria as they are involved in the dissemination of variable genes, including antibiotic resistance and virulence genes leading to generation of hospital ‘superbugs’, as well as catabolic genes lead to formation of new metabolic pathways.

The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

We determined the complete genome sequence of Clostridium difficile strain 630, a virulent and multidrug-resistant strain. Our analysis indicates that a large proportion (11%) of the genome consists

Molecular mechanisms of Escherichia coli pathogenicity

This Review focuses on the recent advances in the understanding of the different pathogenic mechanisms that are used by various E. coli pathovars and how they cause disease in humans.

Phage-Mediated Intergeneric Transfer of Toxin Genes

It is reported that staphylococcal pathogenenicity islands, containing superantigen genes, and other mobile elements transferred to Listeria monocytogenes at the same high frequencies as they transfer within StAPHylococcus aureus.

Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC.

CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

It is shown that CRISPR interference prevents conjugation and plasmid transformation in S. epidermidis and can limit the spread of antibiotic resistance in pathogenic bacteria.

Demonstration of Conjugative Transposon (Tn5397)-Mediated Horizontal Gene Transfer between Clostridium difficile and Enterococcus faecalis

Transfer of the conjugative transposon Tn5397 from C. difficile 630 to E. faecalis JH2-2 is demonstrated, the first reported gene transfer between these two bacteria.

Mobile genetic elements: the agents of open source evolution

This review describes MGEs, their properties that are important in horizontal gene transfer, and current opportunities to advance MGE genomics.
...