Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers

@inproceedings{Brouwer2013HorizontalGT,
  title={Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers},
  author={Michael S. M. Brouwer and Adam P Roberts and Kadhum H. Abdul Hussain and RosamundJ. Williams and Elaine Allan and Peter Mullany},
  booktitle={Nature communications},
  year={2013}
}
Clostridium difficile is a major nosocomial pathogen and the main causative agent of antibiotic-associated diarrhoea. The organism produces two potent toxins, A and B, which are its major virulence factors. These are chromosomally encoded on a region termed the pathogenicity locus (PaLoc), which also contains regulatory genes, and is absent in non-toxigenic strains. Here we show that the PaLoc can be transferred from the toxin-producing strain, 630Δerm, to three non-toxigenic strains of… CONTINUE READING

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