Horizontal cell feedback regulates calcium currents and intracellular calcium levels in rod photoreceptors of salamander and mouse retina.

@article{Babai2009HorizontalCF,
  title={Horizontal cell feedback regulates calcium currents and intracellular calcium levels in rod photoreceptors of salamander and mouse retina.},
  author={Norbert Babai and Wallace B Thoreson},
  journal={The Journal of physiology},
  year={2009},
  volume={587 Pt 10},
  pages={2353-64}
}
We tested whether horizontal cells (HCs) provide feedback that regulates the Ca(2+) current (I(Ca)) of rods in salamander and mouse retinas. In both species, hyperpolarizing HCs by puffing a glutamate antagonist, 6,7-dinitro-quinoxaline-2,3-dione (DNQX), onto HC processes caused a negative shift in the voltage dependence of rod I(Ca) and increased its peak amplitude. Conversely, depolarizing HCs by puffing kainic acid (KA) into the outer plexiform layer (OPL) caused a positive voltage shift and… CONTINUE READING

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