Horizontal Transfer of Tamoxifen Resistance in MCF-7 Cell Derivates: Proteome Study.

@article{Semina2017HorizontalTO,
  title={Horizontal Transfer of Tamoxifen Resistance in MCF-7 Cell Derivates: Proteome Study.},
  author={Svetlana E. Semina and Alexander M Scherbakov and Sergey V Kovalev and Valeriy E. Shevchenko and Mikhail A Krasil'nikov},
  journal={Cancer investigation},
  year={2017},
  volume={35 8},
  pages={506-518}
}
Using estrogen-dependent MCF-7 breast cancer cells and tamoxifen-resistant MCF-7/T subline we have shown that their co-cultivation lead to increase in tamoxifen resistance in the parent MCF-7 cells. The proteome analysis of MCF-7/T cells and new-generated resistant cells revealed 21 common proteins differently expressed in both the resistant cell lines, among them - 6 proteins were associated with the drug or hormonal resistance. Both resistant lines were characterized with suppression of… CONTINUE READING
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