Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.

@article{Takeda2013HopxED,
  title={Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.},
  author={Norifumi Takeda and Rajan Jain and Matthew R Leboeuf and K. Ravi Ananada Padmanabhan and Qiaohong Wang and Li Li and Min Min Lu and Sarah E. Millar and Jonathan A. Epstein},
  journal={Development},
  year={2013},
  volume={140 8},
  pages={
          1655-64
        }
}
The mammalian hair follicle relies on adult resident stem cells and their progeny to fuel and maintain hair growth throughout the life of an organism. The cyclical and initially synchronous nature of hair growth makes the hair follicle an ideal system with which to define homeostatic mechanisms of an adult stem cell population. Recently, we demonstrated that Hopx is a specific marker of intestinal stem cells. Here, we show that Hopx specifically labels long-lived hair follicle stem cells… CONTINUE READING
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