Hoogsteen base-pairing revisited: resolving a role in normal biological processes and human diseases.

@article{Ghosal2006HoogsteenBR,
  title={Hoogsteen base-pairing revisited: resolving a role in normal biological processes and human diseases.},
  author={Gargi Ghosal and Kalappagowda Muniyappa},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={343 1},
  pages={1-7}
}
For a long time since the discovery of an alternative type of hydrogen bonding between adenine and thymidine, termed Hoogsteen base-pairing, its biological role remained elusive. Recent experiments provide compelling evidence that Hoogsteen base pairs manifest in a gamut of nuclear processes encompassing gene expression, replication, recombination, and telomere length maintenance. An increasing number of proteins that have been shown to bind, unwind or cleave G-quadruplexes or triplexes with… CONTINUE READING