Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore.

@article{Li2007HonokiolIA,
  title={Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore.},
  author={Ling Li and Weidong Han and Ying Gu and Shuang Qiu and Qinghua Lu and Jie Jin and Jianhong Luo and Xun Hu},
  journal={Cancer research},
  year={2007},
  volume={67 10},
  pages={
          4894-903
        }
}
Previous reports have shown that honokiol induces apoptosis in numerous cancer cell lines and showed preclinical efficacies against apoptosis-resistant B-cell chronic lymphocytic leukemia and multiple myeloma cells from relapse-refractory patients. Here, we show that honokiol can induce a cell death distinct from apoptosis in HL60, MCF-7, and HEK293 cell lines. The death was characterized by a rapid loss of integrity of plasma membrane without externalization of phosphatidyl serine. The broad… CONTINUE READING

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